1
The renal cells [26,27], esophagus [28,29], breast [30,31], colon [32,33], and prostate [23,34], as well as in endothelial cells [38]. The mechanism that determines the final outcome of IGFBP3 action is not well understood, though some studies suggest a role for post-translational modification [39], localization within specific cellular compartments [25,40], extracellular matrix composition [41],