Changes in cell viability after imatinib. AdIGFBP3 infection alone was cytotoxic relative to Ad-EV at 25 moi (p = 0.0024) (Figure 5). Analyzing imatinib sensitivity after IGFBP3 overexpression with a two-way ANOVA (interaction: p = 0.0009), we observed that imatinib significantly reduced viability in cells infected with AdIGFBP3 or Ad-EV. Furthermore, IGFBP3 overexpression did not significantly al